Romanchishin Endocrinologist Biography

Statistics of incidence and mortality in local breast cancer. Pathogenesis of local breast cancer. Treatment of local breast cancer. Extracuror methods of detoxification in the treatment of breast cancer. Autobiotherapy in the treatment of breast cancer. Chapter 2. Description of the compared groups of patients. Methods of treatment. Characterization of research methods. Chapter 3.

Chapter 4. A histological examination of tumors in the control and main groups. Data of morphometric studies of milk cancer in the studied groups. Histological and morphometric studies of remote lymph nodes. Comparative assessment of morphological and morphometric changes in breast cancer under the influence of various treatment methods. Chapter 5. Study of the content and properties of albumin, medium mass molecules and free-radical processes in autoplasm, its protein concentrate and filtrate.

The state of free radical processes in the liver and its lymphocytes in rats under the influence of various options for the introduction of cyclophosphate. Indicators of endogenous intoxication and free radical oxide in the blood of patients with breast cancer before and after a course of neoadjuvant chemotherapy on the protein concentrate of autoplasm. Chapter 6.

The state of thyroid and glucocorticoid homeostasis in breast cancer patients. The effect of neoadjuvant chemotherapy on the protein concentrate of autoplasm on the hormonal status of patients with breast cancer. Chapter 7. Comparative analysis of the morphological structure of solid -state facies of the protein concentrate of autoplasm for indicators of the system and subsystem organization.

Markers of pathological processes in the facies of protein concentrate of blood plasma with breast cancer. Chapter 8. The results of the effect of polychemiotherapy on the protein concentrate of autoplasm on the structure of adaptive reactions of patients with breast cancer main group. Introduction of the dissertation part of the abstract on the topic "neoadjuvant polychimotherapy on the protein concentrate of autoplasm in the complex treatment of local-fan-grated breast cancer" The relevance of the research on the treatment of breast cancer cancer is one of the urgent problems of modern oncology.

According to Tyulyandin S., the modern approaches of the treatment of breast cancer demonstrate disappointing results. Ways to increase the effectiveness of the treatment of local breast cancer provide for the development of new antitumor drugs, the intensification of chemotherapeutic regimes using drugs for the relief and prevention of toxic chemotherapy effects. The issue of preserving the pre-main intensity of treatment in patients with a high risk of complications, as well as chemotherapy to patients with severe general condition and concomitant pathology, remains unresolved.

All of the above determines the relevance of finding new methods of increasing the effectiveness of antitumor treatment of patients with breast cancer. Sidorenko methods of autobiotherapy, which are based on the principle of using autologous biocations of the body - autocerism, autoplasm, autolimfs, etc. The results of experimental and clinical studies showed the effectiveness of the ongoing chemotherapy when the toxic effect on the body, in which the mechanisms of adaptive regulation of homotics Sidorenko Yu.

Sidorenko are activated. In this regard, the use of autoplasm as a solvent of chemotherapy, where the main active principle is albumin, deserves attention. The latter interacts with the predominant amount of cytostatics in the absence of the effect of competitive binding with blood cells. This is due to its physiological functions in the body and convincingly proven in experimental studies by Sidorenko Yu.

The presence in the plasma component of the blood, in conditions of cancerous intoxication, ballast substances, toxic substances, metabolites of exo- and endogenous origin that interact with albumin, reduces the binding activity of albumin to chemicals. At the same time, the active centers of the albumin turn out to be blocked by these substances Zlatnik E. At the same time, the conformation of albumin also changes.

Protein with altered conformation cannot effectively perform the binding and transport functions.

Existing methods of extorporepal processing and filtration of autoplasm through hemophilters allow not only to detoxify its detoxification with the extraction of pathologically dangerous impurities, but also to get the highest effective concentration of autoalbumin in the unit of plasma volume. The development of the extracorporeal detoxification method will successfully use the method to prepare for special treatment and chemotherapy in somatically weakened patients with the presence of organ dysfunctions.

This will also ensure the preservation of the dose intensity of chemotherapy in patients with a high risk of complications.Sidorenko was proposed a logical solution to the polychimiotherapy of local breast cancer on the autoplasm protein concentrate obtained by filtration detoxification. To improve the direct and closest treatment of the complex treatment of patients with local breast cancer III - IV, as well as in order to reduce general toxic effects on the patient’s body, the study of the role and place of neo -Ajuvant polychimitherapy on the protein concentrate of autoplasm in the complex treatment of patients with this oncopathology.

These issues have determined the purpose and objectives of our research. The purpose of the study: to improve the direct and nearest results of the complex treatment of patients with local breast cancer S-1U stage with concomitant chronic pathology using neoadjuvant polychimiotherapy on the protein concentrate of autoplasm. The goal was achieved by solving the following tasks: 1.

Develop a method of chemotherapy of breast cancer on a protein concentrate of autoplasm obtained by hardware filtration detoxification of the latter. To study the immediate and immediate results of the treatment of patients with the proposed method in comparison with the method of standard chemotherapy. To evaluate the nature and severity of side toxic reactions and the hormonal status of patients with concomitant chronic pathology after neo -Aaduvant chemotherapy on the protein concentrate of autoplasm in comparison with standard chemotherapy.

To study the drug pathomorphosis of the tumor under the influence of neoaduvant chemotherapy on the protein concentrate of autoplasm. To study some biochemical and morphological parameters of the protein plasma concentrate, as well as the toxic effect of cyclophosphena for various options for its introduction in the experiment and the clinic. Determine the nature of adaptive reactions in patients with breast cancer after neo -Aaduvant chemotherapy on autoplasm protein concentrate and explore the structure of autoplasm facies before and after filtration detoxification and cryenization.

The practical significance of the work in detail has developed and tested the method of neoadjuvant chemotherapy on the protein concentrate of autoplasm, which allows you to improve the direct treatment results, increase the operationalness of patients, significantly reduce the toxicity of the therapy, increase the general and rendered survival of patients. The studies can recommend the method in the complex treatment of patients with local breast cancer with concomitant chronic pathology.

The introduction of the research results in the practice of healthcare, the method of neoadjuvant chemotherapy on the protein concentrate of autoplasm has been introduced and is used in the clinic of the Rostov Research oncology Institute, the City Oncological Dispensary. The main situation, which is protected in the treatment of patients with local breast cancer with concomitant chronic pathology, is advisable to use neoaduvant chemotherapy on autoplasm protein concentrate.

The test of the dissertation Thesis was tested at a meeting of the Academic Council of the Rostov Research on the Oncology Institute on February 25. Publications on the topic of the dissertation published 21 scientific work. The structure and volume of the dissertation is set out on the pages and consists of the introduction, review of literature, descriptions of research methods, 6 chapters on the results of research, conclusions, conclusions, practical recommendations and pointer of literature, which includes domestic and foreign publications.

The work is illustrated by 37 tables and 38 drawings. The use of the protein concentrate of autoplasm for chemotherapy allows you to reduce the toxic effect of chemotherapy on the hematopoietic system and the gastrointestinal tract concomitant pathology, which was important, since it allowed the dose -intensative treatment for treatment and introduce chemotherapy in the complete course dose in patients with the accompanying chronic pathology of organs hepatobiliary zone.

The results of the bioadaptive influence of two courses of chemotherapy on the protein concentrate of autoplasm can be interpreted as a gradual inclusion of anti -stress -based mechanisms: a decrease in the frequency of stress development, maintaining a persistent training reaction and dynamic transitions from more energy -intensive activation states into balanced calm activation regimes, which indicates the physiological effect of exposure to exposure to The body, at the same time, occurs the preserved dys regulatory state of the mechanisms responsible for maintaining the physiologically normal thyroid and glucocorticoid status of the body of patients with breast cancer.

The animal experiment shows that the introduction of cyclophosphen on the protein concentrate of blood plasma protects hepatocytes and lymphocytes of the liver tissue from oxidative stress, which inevitably occurs when cytostatics on a traditional solvent and leads to damage to their membranes. This can serve as a substantiation of the use of this type of treatment in the clinic in cancer patients with the concomitant chronic pathology of the hepatobilliary organs.

To increase the efficiency and reduce the toxicity of neoadjuvant chemotherapy of local-produced breast cancer, it is advisable to use PCT on a protein concentrate obtained by filtering detoxification of autoplasm. Pathogenetically substantiated is the use of PHT on the protein concentrate of autoplasm in the treatment of breast cancer in patients suffering from concomitant chronic pathology of the hepatobiliary zone organs.

List of literature of the dissertation research 1. Abduliev A. Abramova H. Modified autohemochemotherapy using richlocaine in neo-theaduvant treatment of breast cancer: Auto-Ref. Ayrapetov K. Traditional and modified auto-chemotherapy in the complex treatment of patients with non-Journal lymphomas: Auto-Ref. Akmayev I. Ametov A. Amiramishanov A. Andryukhin V.

Afanasyev V. Markova and others. Afonina G. Baevsky P. Assessment of the adaptive capabilities of the body and the risk of the development of diseases. Baryshnikov A. Ross, oncologist, conf. Baum M. Belyakov S. Belyakov H. Belski A. Biryukov A. Automilochemotherapy in the treatment of relapses of ovarian cancer: dis. Blokhin S. Bogush T. Bondar G. Oleinikov K. Bordyushkov Yu.

Bardokhivskaya K.