Vladimir Anisimov Biography

Erlich and the diploma “For special merits in the field of social and preventive medicine” by the European Academy of Natural and Social Sciences Hanover, Germany Medal and the Honorary Diploma “For outstanding achievements in the study of aging and contribution to the development of gerontological science in Europe”, the European Department of the International Association of Gerontology and Gerriah of Oncology named after Petrova Medal named after Professor N.

Petrov “For outstanding merits in oncology” “Everything else that I also own, I give you, please take you ...” V. Anisimov Vladimir Nikolaevich Anisimov was born on December 7 in Leningrad in a military family. In the first grade he went in Kaliningrad in the year, six months later he returned to Leningrad, and already in the year of his father he was sent to serve in the Red Banner Far Eastern Military District.

In the year, it was announced that schools were introduced in schools, so V. Anisimov decided to enter the Feldsher school in order to get a specialty in the same 4 years of study. In the year, the father was demobilized, and the family returned to Leningrad. In the year, V. Anisimov graduated with honors from the 2nd Leningrad Medical School and entered the 1st Leningrad Medical Institute.

Studying in the 3rd year, Vladimir Nikolaevich joins the work of the laboratory of tumor strains at the Institute of Oncology of the Academy of Medical Sciences of the USSR, which is inextricably linked by almost 60 years of scientific and research activity of V. during his studies at the institute repeatedly as part of the student construction detachment, went to the construction sites of Kazakhstan, the Far East and the Leningrad Region.

For the development of the virgin and deposit lands of Kazakhstan, he was awarded the state award by the medal “For the development of virgin lands” with honors by graduating from the 1st Leningrad Medical Institute, Vladimir Nikolaevich enters the clinical residency at the Research Institute of Oncology named after Petrova MZ of the USSR, where he actively continues to engage in research work, the logical completion of which was the defense of the dissertation for the degree of candidate of medical sciences in November.

Anisimov went through the scientist's thorny path from the laboratory assistant with the higher education of the laboratory of experimental tumors to the head of the department of carcinogenesis and oncorerontology. Pavlova, G, the main area of ​​scientific activity of V. Anisimov is associated with the study of the laws and mechanisms of the relationship of ontogenesis and carcinogenesis.

Napalkov and the author of eleval ontogenetic theory of aging by Professor V. The first studies of V. Anisimov were devoted to the study of the characteristics of the occurrence of tumors in conditions of impaired hormonal balance in the body. In experiments on mice and rats, it was found that the effects of various chemical carcinogenic agents are accompanied by accelerated development of animal hormonal and metabolic disorders characteristic of natural aging and contributing to the implementation of the process of carcinogenesis.

The induction in females of rats of constant estrus syndrome, also accompanied by a number of signs of accelerated aging, had a stimulating effect on the development of neoplasms. These observations became the key to all subsequent scientific activity by V. Professor V. Anisimov experimentally established the basic laws of the modifying effect of age on the sensitivity of the body to the action of various exogenous and endogenous carcinogens, which underlie the mechanism of age -related increase in the frequency of malignant neoplasms.

The role of the age dynamics of the activity of enzyme systems, metabolizing carcinogens, DNA reparation systems, proliferative activity of target tissue in a change in their sensitivity to the initiating effect of carcinogenic agents of various nature of chemical, radiation, hormonal. It is shown that hormonal-metabolic and immunological disorders developing in the body during aging contribute to carcinogenesis.

It was established that with age, cells accumulate in the tissues of the body, which have been randomly exposed to carcinogenic agents and have passed in accordance with the multi -stage model of carcinogenesis more than one stage on the way to its complete malformation. The impact on these cells of the late stages of carcinogens and tumor promoters in old animals invariably causes neoplasms in target tissues with a higher speed and a shorter latent period than in younger animals.

For the first time, Vladimir Nikolayevich Anisimov revealed the ability of antidiabetic beiguanides to increase the life expectancy of animals and slow down carcinogenesis, which has opened a new direction in modern gerontology and oncology-to study the role of the insulin-intensible growth factor-1-glucose in aging and carcinogens, the use of metformin for the prevention of tumors and the development of tumors and premature aging in humans.

Anisimov made a great contribution to the study of the role of the pineal gland of the pineal gland in tumor growth and the aging process.Under his leadership, it was found that the content of animals in constant lighting, inhibiting the function of the epiphyse, helps to accelerate aging and the development of tumors, while the use of the hormone of the epiphysis of melatonin has the opposite effect.

The results of these studies formed the basis of the evidence base for recognition by the International Agency for the Study of Cancer Mair of Light Pollution by carcinogenic for humans and were reflected in the monograph by IARC Monographs Vol. Carcinogenicity of Night Shift Work Anisimov is the author of more scientific papers, including 20 monographs and guidelines published both in Russia and abroad Germany, the USA, France, Switzerland, PR.

Anisimov is one of the most cited Russian scientists. Prepared 11 doctors and 27 candidates of sciences. Anisimova is an active organizer and head of scientific research, whose professionalism is recognized around the world. Petrova »Ministry of Health of Russia.